2025-01-31 15-33-37
Content
- Following a Ketogenic Diet with blood Beta-Hydroxybutyrate (BHB) levels ~1.4-2.0 mM intermittently may be better than following it continuously, regardless of protein intake, due to the accumulation of Senescent Cells.
References
| Quick Notes6 | |
|---|---|
| 2025-01-31 16-36-26 | Following a Ketogenic Diet continuously for 6 months while maintaining blood Beta-Hydroxybutyrate (BHB) levels between 0.5-3.0 mM can increase circulating markers of Senescence-Associated Secretory Phenotype. |
| 2025-01-31 15-57-25 | The accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice following a Ketogenic Diet is reversed upon stopping the diet. |
| 2025-01-31 15-53-41 | A Ketogenic Diet causes the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice via an increase in p53 activity. |
| 2025-01-31 15-26-35 | An intermittent Ketogenic Diet does not cause the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice compared to a control diet or to a continuous ketogenic diet |
| 2025-01-31 15-16-59 | A Ketogenic Diet can cause the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice compared to a control diet independent of weight when Beta-Hydroxybutyrate (BHB) levels are maintained ~1.4-1.8 mM in the ketogenic group and ~0.8-1.0 mM in the control group. Ketogenic diet protein composition 10% of calories and control diet protein composition 10% of calories. |
| 2025-01-31 14-40-42 | A Ketogenic Diet can cause the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice compared to a control diet independent of weight when blood Beta-Hydroxybutyrate (BHB) levels are maintained ~1.4-2.0 mM in the ketogenic diet group and ~0.8-0.9 mM in the control group. Ketogenic diet protein composition 9.2% of calories vs. control diet protein composition 25% of calories. |
| Original Sources2 | Citations |
|---|---|
| weiKetogenicDietInduces2024 | Wei, Sung-Jen, Joseph R. Schell, E. Sandra Chocron, Mahboubeh Varmazyad, Guogang Xu, Wan Hsi Chen, Gloria M. Martinez, et al. “Ketogenic Diet Induces P53-Dependent Cellular Senescence in Multiple Organs.” Science Advances 10, no. 20 (May 17, 2024): eado1463. https://doi.org/10.1126/sciadv.ado1463. |
| duTechnologyAssistedPrecision2022 | Du, Yan, Jing Wang, Shiyu Li, Brittany Dennis, Christiane Meireles, Nazishi Siddiqui, Darpan Patel, et al. “A Technology Assisted Precision Ketogenic Diet Intervention for Cardio-Renal-Metabolic Health in Overweight or Obese Adults: Protocol for a Randomized Controlled Trial.” Contemporary Clinical Trials 119 (August 1, 2022): 106845. https://doi.org/10.1016/j.cct.2022.106845. |