2025-01-31 14-37-21

Content

A protein-restricted Ketogenic Diet may reduce the progression of Osteoarthritis when blood Beta-Hydroxybutyrate (BHB) levels are maintained ~3.0 mM and there is no weight loss.

References

Assumptions1
2025-01-31 15-13-30	Protein intake does not impact the effect of a ketogenic diet on Osteoarthritis progression

Quick Notes2
2025-01-31 14-23-42	A Ketogenic Diet can worsen the progression of Knee Osteoarthritis in mice who maintain Beta-Hydroxybutyrate (BHB) levels ~ 1.28 mM compared to control rats with BHB levels ~0.87 mM when ketogenic-diet-fed mice lose weight post-injury and control mice do not. This is potentially due to ketogenic-diet-induced changes in the Gut Microbiome. Ketogenic diet protein composition 22.4% of calories and control diet protein composition 24% of calories.
2025-01-28 19-22-32	A Ketogenic Diet can reduce the progression of Knee Osteoarthritis via inhibition of the NLRP3 Inflammasome in rats who maintain Beta-Hydroxybutyrate (BHB) levels ~ 3.0 mM compared to control rats with BHB levels ~0.4-0.8 mM independent of weight. Ketogenic diet protein composition ~10.9% kcal and control diet protein composition ~18.3% kcal.

Quick Notes2

2025-01-31 14-23-42

A Ketogenic Diet can worsen the progression of Knee Osteoarthritis in mice who maintain Beta-Hydroxybutyrate (BHB) levels ~ 1.28 mM compared to control rats with BHB levels ~0.87 mM when ketogenic-diet-fed mice lose weight post-injury and control mice do not. This is potentially due to ketogenic-diet-induced changes in the Gut Microbiome. Ketogenic diet protein composition 22.4% of calories and control diet protein composition 24% of calories.

2025-01-28 19-22-32

A Ketogenic Diet can reduce the progression of Knee Osteoarthritis via inhibition of the NLRP3 Inflammasome in rats who maintain Beta-Hydroxybutyrate (BHB) levels ~ 3.0 mM compared to control rats with BHB levels ~0.4-0.8 mM independent of weight. Ketogenic diet protein composition ~10.9% kcal and control diet protein composition ~18.3% kcal.

Original Sources2	Citations
kongKetogenicDietAmeliorates2022	Kong, Ganggang, Jinyang Wang, Rong Li, Zhiping Huang, and Le Wang. “Ketogenic Diet Ameliorates Inflammation by Inhibiting the NLRP3 Inflammasome in Osteoarthritis.” Arthritis Research & Therapy 24, no. 1 (May 18, 2022): 113. https://doi.org/10.1186/s13075-022-02802-0.
dysonKetogenicDietAssociatedWorsening2025	Dyson, Gabby, Montana Barrett, Leoni Schlupp, Emmaline Prinz, Nicholas Hannebut, Aleksander Szymczak, Cindy Miranda Brawner, and Matlock A. Jeffries. “Ketogenic Diet-Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice.” ACR Open Rheumatology 7, no. 1 (January 2025): e11794. https://doi.org/10.1002/acr2.11794.