2025-01-28 20-12-29

Content

References

Assumptions4
2025-01-28 21-20-02The effect of Urolithin A on Intervertebral Disc (IVD) degeneration in response to IVD puncture is the same for rats of all ages
2025-01-28 21-03-50Intervertebral Disc (IVD) degeneration progresses similarly between rats and humans
2025-01-28 21-02-30Intervertebral Disc (IVD) degeneration progresses similarly amongst rats of all ages in response to a puncture model
2025-01-28 20-53-52An Intervertebral Disc (IVD) puncture is an appropriate model for assessing IVD degeneration in rats
Insights4
2025-01-30 15-34-35Urolithin A slows the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-33-56Urolithin A slows the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 12 weeks of age compared to rats not fed urolithin A
2025-01-30 15 28 41Urolithin A reduces the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 8 weeks of age compared to rats not fed urolithin A
2025-01-29 10-41-13A Urolithin A dose of 25 mg/kg/day in a rat equates to 4 mg/kg/day in a human
Original Sources4Citations
usfdaEstimatingMaximumSafe2018USFDA. “Estimating the Maximum Safe Starting Dose in Initial Clinical Trials for Therapeutics in Adult Healthy Volunteers.” FDA, December 1, 2018. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/estimating-maximum-safe-starting-dose-initial-clinical-trials-therapeutics-adult-healthy-volunteers.
linUrolithinAinducedMitophagy2020Lin, Jialiang, Jinru Zhuge, Xuanqi Zheng, Yuhao Wu, Zengjie Zhang, Tianzhen Xu, Zaher Meftah, et al. “Urolithin A-Induced Mitophagy Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the AMPK Signaling Pathway.” Free Radical Biology & Medicine 150 (April 2020): 109–19. https://doi.org/10.1016/j.freeradbiomed.2020.02.024.
liuUrolithinInhibitsCatabolic2018Liu, Huiyong, Honglei Kang, Chao Song, Zuowei Lei, Li Li, Jianfeng Guo, Yong Xu, Hanfeng Guan, Zhong Fang, and Feng Li. “Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration in Vivo.” Frontiers in Pharmacology 9 (2018): 1043. https://doi.org/10.3389/fphar.2018.01043.
shiUrolithinAlleviatesOxidative2021Shi, Peng-Zhi, Jun-Wu Wang, Ping-Chuan Wang, Bo Han, Xu-Hua Lu, Yong-Xin Ren, Xin-Min Feng, Xiao-Fei Cheng, and Liang Zhang. “Urolithin a Alleviates Oxidative Stress-Induced Senescence in Nucleus Pulposus-Derived Mesenchymal Stem Cells through SIRT1/PGC-1α Pathway.” World Journal of Stem Cells 13, no. 12 (December 26, 2021): 1928–46. https://doi.org/10.4252/wjsc.v13.i12.1928.