2025-01-28 20-11-31

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2025-01-30 14-40-02The reduction in circulating IGF1 availability during fasting is responsible for the fasting-induced symmetric Self-Renewal of mouse Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) after 72-hour Prolonged Fasting
2025-01-29 11-24-44Prolonged Fasting for 72 hours induces symmetric Self-Renewal of mouse Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs)
2025-01-29 10-35-559 days of water-only Prolonged Fasting in humans is equivalent to a 3-day water-only fast in mice in terms of its effects on IGF1 availability
Original Sources3Citations
chengProlongedFastingReduces2014Cheng, C.-W., Adams, G.B., Perin, L., Wei, M., Zhou, X., Lam, B.S., Da Sacco, S., Mirisola, M., Quinn, D.I., Dorff, T.B., Kopchick, J.J., Longo, V.D., 2014. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell 14, 810–823. https://doi.org/10.1016/j.stem.2014.04.014
leeReducedLevelsIGFI2010Lee, C., Safdie, F.M., Raffaghello, L., Wei, M., Madia, F., Parrella, E., Hwang, D., Cohen, P., Bianchi, G., Longo, V.D., 2010. Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index. Cancer Research 70, 1564–1572. https://doi.org/10.1158/0008-5472.CAN-09-3228
clemmonsReductionPlasmaImmunoreactive1981CLEMMONS, D.R., KLIBANSKI, A., UNDERWOOD, L.E., McARTHUR, J.W., RIDGWAY, E.C., BEITINS, I.Z., VAN WYK, J.J., 1981. Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*. The Journal of Clinical Endocrinology & Metabolism 53, 1247–1250. https://doi.org/10.1210/jcem-53-6-1247