2025-01-28 20-08-19

Content

References

Assumptions1
2025-01-28 21-32-52The reduction in IGF1 availability during a fast is responsible for the effects of Prolonged Fasting and Refeeding on Senescent Cells
Insights2
2025-01-30 13-54-39Refeeding after a Fasting-Mimicking Diet (FMD) causes Senescent Cells of various types throughout the body to die off
2025-01-29 10-27-593 days of water-only Prolonged Fasting is at least equivalent to a 4-day mouse Fasting-Mimicking Diet (FMD) in terms of its effects on IGF1 availability
Original Sources5Citations
clemmonsReductionPlasmaImmunoreactive1981CLEMMONS, D.R., KLIBANSKI, A., UNDERWOOD, L.E., McARTHUR, J.W., RIDGWAY, E.C., BEITINS, I.Z., VAN WYK, J.J., 1981. Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*. The Journal of Clinical Endocrinology & Metabolism 53, 1247–1250. https://doi.org/10.1210/jcem-53-6-1247
merimeeInsulinlikeGrowthFactors1982Merimee, T.J., Zapf, J., Froesch, E.R., 1982. Insulin-like growth factors in the fed and fasted states. J Clin Endocrinol Metab 55, 999–1002. https://doi.org/10.1210/jcem-55-5-999
isleyDietaryComponentsThat1983Isley, W.L., Underwood, L.E., Clemmons, D.R., 1983. Dietary components that regulate serum somatomedin-C concentrations in humans. J Clin Invest 71, 175–182. https://doi.org/10.1172/JCI110757
brandhorstPeriodicDietThat2015Brandhorst, S., Choi, I.Y., Wei, M., Cheng, C.W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L.P., Park, R., Vinciguerra, M., Di Biase, S., Mirzaei, H., Mirisola, M.G., Childress, P., Ji, L., Groshen, S., Penna, F., Odetti, P., Perin, L., Conti, P.S., Ikeno, Y., Kennedy, B.K., Cohen, P., Morgan, T.E., Dorff, T.B., Longo, V.D., 2015. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab 22, 86–99. https://doi.org/10.1016/j.cmet.2015.05.012
longoUtilizationFastingMimickingDiet2023Longo, V.D., Brandhorst, S., Guidi, N., Crupi, A.N., 2023. Utilization of a Fasting-Mimicking Diet to Reduce Senescent Cells and Inflammation. 20230037534.