Senescent Cells

Tagged Content

Takeaways2
2025-01-31 15-33-37Following a Ketogenic Diet with blood Beta-Hydroxybutyrate (BHB) levels ~1.4-2.0 mM intermittently may be better than following it continuously, regardless of protein intake, due to the accumulation of Senescent Cells.
2025-01-28 20-08-19Refeeding after Prolonged Fasting for at least 3 days may induce whole-body reduction of Senescent Cells
Insights6
2025-01-30 14-58-12Two consecutive monthly Fasting-Mimicking Diet (FMD) cycles can reduce the number of Senescent Cells throughout the body
2025-01-30 14-57-31There are fewer Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) Senescent Cells in the bone marrow of mice 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 14-13-57Senescent Cells accumulate throughout the body with Aging
2025-01-30 14-05-50Refeeding causes Apoptosis in Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) Senescent Cells following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 13-54-39Refeeding after a Fasting-Mimicking Diet (FMD) causes Senescent Cells of various types throughout the body to die off
2025-01-30 13-53-46Refeeding after an Fasting-Mimicking Diet (FMD) cycle causes a reduction in Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) Senescent Cells specifically due to Apoptosis
Quick Notes7
2025-01-31 16-10-26In vitro exposure of Human Umbilical Vein Endothelial Cells (HUVECs) to 4 mM Acetoacetate (AcAc) does not reduce the accumulation of Senescent Cells.
2025-01-31 16-08-45In vitro exposure of Human Umbilical Vein Endothelial Cells (HUVECs) to 4 mM Beta-Hydroxybutyrate (BHB) reduces the accumulation of Senescent Cells.
2025-01-31 15-57-25The accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice following a Ketogenic Diet is reversed upon stopping the diet.
2025-01-31 15-53-41A Ketogenic Diet causes the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice via an increase in p53 activity.
2025-01-31 15-26-35An intermittent Ketogenic Diet does not cause the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice compared to a control diet or to a continuous ketogenic diet
2025-01-31 15-16-59A Ketogenic Diet can cause the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice compared to a control diet independent of weight when Beta-Hydroxybutyrate (BHB) levels are maintained ~1.4-1.8 mM in the ketogenic group and ~0.8-1.0 mM in the control group. Ketogenic diet protein composition 10% of calories and control diet protein composition 10% of calories.
2025-01-31 14-40-42A Ketogenic Diet can cause the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice compared to a control diet independent of weight when blood Beta-Hydroxybutyrate (BHB) levels are maintained ~1.4-2.0 mM in the ketogenic diet group and ~0.8-0.9 mM in the control group. Ketogenic diet protein composition 9.2% of calories vs. control diet protein composition 25% of calories.
Assumptions2
2025-01-28 21-32-52The reduction in IGF1 availability during a fast is responsible for the effects of Prolonged Fasting and Refeeding on Senescent Cells
2025-01-28 21-19-18The effect of Fasting-Mimicking Diet (FMD) cycles on Senescent Cells does not depend on age