Osteoarthritis

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Takeaways3
2025-01-31 14-37-21A protein-restricted Ketogenic Diet may reduce the progression of Osteoarthritis when blood Beta-Hydroxybutyrate (BHB) levels are maintained ~3.0 mM and there is no weight loss.
2025-01-28 20-20-37A Urolithin A dose of at least 20.3 mg/kg/day may reduce the pain from Osteoarthritis
2025-01-28 20-19-26A Urolithin A dose of at least 20.3 mg/kg/day may reduce the progression of Osteoarthritis
Insights10
2025-01-30 15-30-53Urolithin A reduces the serum levels of Matrix Metalloproteinase-3 (MMP3) in mice at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-26-59Urolithin A reduces the knee OARSI score of mice at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-23-29Urolithin A reduces markers of the progression of knee Osteoarthritis at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-23-01Urolithin A may reduce the pain response to a 4g Von Frey filament at a dose of either 250 mg/kg/day or 50 mg/kg/day compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-21-19Urolithin A may reduce the pain response to a 4g Von Frey filament at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 4 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-20-59Urolithin A may reduce the pain from knee Osteoarthritis in mice at a dose of either 250 mg/kg/day or 50 mg/kg/day when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-18-57Urolithin A may reduce knee Sinovitis at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-18-26Urolithin A increases the cell number in non-calcified knee Cartilage of mice at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-11-44Urolithin A can reduce the pain response to a 1g Von Frey filament at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-29 10-43-15A Urolithin A dose of 250 mg/kg/day is likely better than a dose of 50 mg/kg/day at reducing the pain from knee Osteoarthritis in mice when taken for 8 weeks after the induction of experimental arthritis at 4 months of age
Quick Notes2
2025-01-31 14-23-42 A Ketogenic Diet can worsen the progression of Knee Osteoarthritis in mice who maintain Beta-Hydroxybutyrate (BHB) levels ~ 1.28 mM compared to control rats with BHB levels ~0.87 mM when ketogenic-diet-fed mice lose weight post-injury and control mice do not. This is potentially due to ketogenic-diet-induced changes in the Gut Microbiome. Ketogenic diet protein composition 22.4% of calories and control diet protein composition 24% of calories.
2025-01-28 19-22-32A Ketogenic Diet can reduce the progression of Knee Osteoarthritis via inhibition of the NLRP3 Inflammasome in rats who maintain Beta-Hydroxybutyrate (BHB) levels ~ 3.0 mM compared to control rats with BHB levels ~0.4-0.8 mM independent of weight. Ketogenic diet protein composition ~10.9% kcal and control diet protein composition ~18.3% kcal.
Assumptions7
2025-01-31 15-13-30Protein intake does not impact the effect of a ketogenic diet on Osteoarthritis progression
2025-01-28 21-34-31The progression of knee Osteoarthritis in damicoUrolithinImprovesMitochondrial2022 is similar to that of humans
2025-01-28 21-35-03The progression of all types of Osteoarthritis is equally sensitive to treatment by Urolithin A
2025-01-28 21-29-23The pain from all types of Osteoarthritis is equally sensitive to treatment by Urolithin A
2025-01-28 21-31-22The progression of pain from knee Osteoarthritis in mice in damicoUrolithinImprovesMitochondrial2022 is similar to that of humans
2025-01-28 21-16-36The knee Sinovitis observed in the model of knee Osteoarthritis in damicoUrolithinImprovesMitochondrial2022 is relevant to humans
2025-01-28 20-49-14A Von Frey test is an appropriate test for assessing pain for knee Osteoarthritis in mice