Ketogenic Diet

Tagged Content

Takeaways3
2025-02-02 14-35-28A Ketogenic Diet can reduce serum Bicarbonate levels
2025-01-31 15-33-37Following a Ketogenic Diet with blood Beta-Hydroxybutyrate (BHB) levels ~1.4-2.0 mM intermittently may be better than following it continuously, regardless of protein intake, due to the accumulation of Senescent Cells.
2025-01-31 14-37-21A protein-restricted Ketogenic Diet may reduce the progression of Osteoarthritis when blood Beta-Hydroxybutyrate (BHB) levels are maintained ~3.0 mM and there is no weight loss.
Insights6
2025-01-20 19-52-51Fewer Muscle Stem Cells (MuSCs, Satellite Stem Cells) enter S Phase when cultured ex vivo when the stem cells are isolated from mice following a Ketogenic Diet for 3 weeks compared to mice on a standard diet as assessed by EdU incorporation
2025-01-20 19-47-43Muscle Stem Cells (MuSCs, Satellite Stem Cells) have ~40% reduced content of Mitochondria (number and/or size) in mice after following a Ketogenic Diet for 3 weeks compared to mice on a control diet as assessed by MitoTracker
2025-01-20 19-43-12Muscle Stem Cells (MuSCs, Satellite Stem Cells) enter a state of Deep Quiescence at the end of 3 weeks on a Ketogenic Diet in mice
2025-01-20 19-40-29Muscle Stem Cells (MuSCs, Satellite Stem Cells) are reduced in size by ~10% in mice who followed a Ketogenic Diet for 3 weeks compared with mice on a control diet
2025-01-20 16-54-40Following a Ketogenic Diet for 3 weeks prior to and after muscle injury reduces muscle Regeneration at 7 days post-injury compared to following a standard diet prior to and following injury
2025-01-20 16-46-34Mice following a Ketogenic Diet for 20 days have a blood Beta-Hydroxybutyrate (BHB) level of ~2.1 mM
Quick Notes15
2025-02-02 14-49-48Triiodothyronine (T3) levels decrease by ~40% when switching to a Ketogenic Diet
2025-02-02 14-48-08Serum Free Fatty Acids (FFA) increase when switching to a Ketogenic Diet
2025-02-02 14-46-23Serum Uric Acid levels increase when switching to a Ketogenic Diet
2025-02-02 14-33-50Serum Bicarbonate levels are reduced when switching to a Ketogenic Diet
2025-02-02 14-31-46Serum Alkaline Phosphatase (ALP) levels do not change when switching to a Ketogenic Diet
2025-01-31 16-36-26Following a Ketogenic Diet continuously for 6 months while maintaining blood Beta-Hydroxybutyrate (BHB) levels between 0.5-3.0 mM can increase circulating markers of Senescence-Associated Secretory Phenotype.
2025-01-31 15-57-25The accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice following a Ketogenic Diet is reversed upon stopping the diet.
2025-01-31 15-53-41A Ketogenic Diet causes the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice via an increase in p53 activity.
2025-01-31 15-26-35An intermittent Ketogenic Diet does not cause the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice compared to a control diet or to a continuous ketogenic diet
2025-01-31 15-16-59A Ketogenic Diet can cause the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice compared to a control diet independent of weight when Beta-Hydroxybutyrate (BHB) levels are maintained ~1.4-1.8 mM in the ketogenic group and ~0.8-1.0 mM in the control group. Ketogenic diet protein composition 10% of calories and control diet protein composition 10% of calories.
2025-01-31 14-40-42A Ketogenic Diet can cause the accumulation of Senescence-Associated Beta-Galactosidase (SA-β-gal)/Senescent Cells in multiple organs in mice compared to a control diet independent of weight when blood Beta-Hydroxybutyrate (BHB) levels are maintained ~1.4-2.0 mM in the ketogenic diet group and ~0.8-0.9 mM in the control group. Ketogenic diet protein composition 9.2% of calories vs. control diet protein composition 25% of calories.
2025-01-31 14-23-42 A Ketogenic Diet can worsen the progression of Knee Osteoarthritis in mice who maintain Beta-Hydroxybutyrate (BHB) levels ~ 1.28 mM compared to control rats with BHB levels ~0.87 mM when ketogenic-diet-fed mice lose weight post-injury and control mice do not. This is potentially due to ketogenic-diet-induced changes in the Gut Microbiome. Ketogenic diet protein composition 22.4% of calories and control diet protein composition 24% of calories.
2025-01-28 19-22-32A Ketogenic Diet can reduce the progression of Knee Osteoarthritis via inhibition of the NLRP3 Inflammasome in rats who maintain Beta-Hydroxybutyrate (BHB) levels ~ 3.0 mM compared to control rats with BHB levels ~0.4-0.8 mM independent of weight. Ketogenic diet protein composition ~10.9% kcal and control diet protein composition ~18.3% kcal.
2025-01-23 18-12-27Blood pH does not change before vs. after following a Ketogenic Diet
2025-01-23 18-09-03Nutritional Ketosis is achieved by day 3 of a Ketogenic Diet
Assumptions2
2025-01-20 16-49-31The blood Beta-Hydroxybutyrate (BHB) level of mice did not change between day 20 of a Ketogenic Diet and when they were sacrificed post-injury in benjaminFastingInducesHighly2022
2025-01-20 16-43-48Mice in the Ketogenic Diet group continued to be fed a ketogenic diet during the 7 days following injury prior to sacrifice in benjaminFastingInducesHighly2022