Intervertebral Disc (IVD)

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Takeaways4
2025-01-30 12-16-01Back Pain in the Lumbar Spine can be reduced within 3 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into a non-torn Intervertebral Disc (IVD) at L5-S1, L4-L5, or both levels
2025-01-28 20-17-29Intervertebral Disc (IVD) height is not changed within 12 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into a non-torn Intervertebral Disc (IVD) at L5-S1, L4-L5, or both levels
2025-01-28 20-16-12Intervertebral Disc (IVD) hydration can be increased within 12 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into a non-torn Intervertebral Disc (IVD) at L5-S1, L4-L5, or both levels
2025-01-28 20-12-29A Urolithin A dose of at least 4 mg/kg/day may reduce the progression of Intervertebral Disc (IVD) degeneration
Insights33
2025-01-30 15-28-05Urolithin A reduces the number of TUNEL-positive cells in the Nucleus Pulposus at a dose of 25 mg/kg/day when taken for 4 weeks after an Intervertebral Disc (IVD) puncture at 8 weeks of age compared to rats not fed urolithin A
2025-01-30 15-37-02Urolithin A slows the reduction in Intervertebral Disc (IVD) histological score at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-35-56Urolithin A slows the progressive loss of Intervertebral Disc (IVD) height at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 12 weeks of age compared to rats not fed Urolithin A
2025-01-30 15-34-35Urolithin A slows the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-34-20Urolithin A slows the progression of Pfirrmann Grade at a dose of 25 mg/kg/day when taken for 4 weeks after an Intervertebral Disc (IVD) puncture at 12 weeks of age compared to rats not fed urolithin A
2025-01-30 15-33-56Urolithin A slows the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 12 weeks of age compared to rats not fed urolithin A
2025-01-30 15-32-27Urolithin A slows the progression in Intervertebral Disc (IVD) Pfirrmann Grade at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-31-32Urolithin A slows the increase in histologic score at a dose of 25 mg/kg/day when taken for 4 weeks after an Intervertebral Disc (IVD) puncture at 12 weeks of age compared to rats not fed urolithin A
2025-01-30 14-02-08Neuropathy and/or Chemical Radiculitis can be resolved within 12 weeks of injecting 10X Platelet-Rich Plasma (PRP) into the Intervertebral Disc (IVD)
2025-01-30 15-25-18Urolithin A reduces the Intervertebral Disc (IVD) histological score at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 8 weeks of age compared to rats not fed urolithin A
2025-01-30 15-24-17Urolithin A reduces the Intervertebral Disc (IVD) Pfirrmann Grade at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 8 weeks of age compared to rats not fed urolithin A
2025-01-30 15-17-08Urolithin A increases the Intervertebral Disc (IVD) disc height index at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-15-20Urolithin A increases the Intervertebral Disc (IVD) Collagen Type II fluorescence at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-14-32Urolithin A increases the Intervertebral Disc (IVD) Aggrecan fluorescence at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15 28 41Urolithin A reduces the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 8 weeks of age compared to rats not fed urolithin A
2025-01-30 14-48-20The number of Hypoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) injected into the Annulus Fibrosus of a torn L5-S1 Intervertebral Disc (IVD) may positively correlate with overall improvement in quality of life after 4+ years
2025-01-30 14-29-17The ideal single dose for injecting Hypoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into the Annulus Fibrosus of a torn L5-S1 Intervertebral Disc (IVD) to improve overall quality of life after 4+ years may be 35.9 million cells
2025-01-30 14-13-16Sciatica is reduced by an average of 86% at 12 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into the Intervertebral Disc (IVD)
2025-01-30 14-12-07Sciatica is reduced by an average of 79% at 6 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into the Intervertebral Disc (IVD)
2025-01-30 14-08-07Sciatica is not significantly reduced at 3 months after after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into a non-torn Intervertebral Disc (IVD) at L5-S1, L4-L5, or both levels
2025-01-30 12-15-27Back Pain in the Lumbar Spine is reduced by an average of 71% at 12 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into a non-torn Intervertebral Disc (IVD) at L5-S1, L4-L5, or both levels
2025-01-30 12-13-47Back Pain in the Lumbar Spine is reduced by an average of 69% at 6 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into a non-torn Intervertebral Disc (IVD) at L5-S1, L4-L5, or both levels
2025-01-30 12-11-56Back Pain in the Lumbar Spine is reduced by an average of 62% at 3 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into a non-torn Intervertebral Disc (IVD) at L5-S1, L4-L5, or both levels
2025-01-30 12-06-46Injecting leukocyte-rich >10X Platelet-Rich Plasma (PRP) into a pain-generating Intervertebral Disc (IVD) is successful in 70% of patients as assessed by NRS pain score, FRI, and patient satisfaction
2025-01-29 10-55-56Discopathy should be the term used to collectively refer to Intervertebral Disc (IVD) bulges and disc protrusions and discs with normal contours but abnormal heights and-or T2 signal intensities on Magnetic Resonance Imaging (MRI)
2025-01-29 10-54-58Intervertebral Disc (IVD) hydration is increased by an average of 16% at 12 months after intradiscal injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs)
2025-01-29 10-53-58Intervertebral Disc (IVD) bulges, disc protrusions, and discs with normal contours but abnormal heights and-or T2 signal intensities on Magnetic Resonance Imaging (MRI) are highly likely to indicate the presence of a tear in the inner Annulus Fibrosus
2025-01-29 10-52-14Intervertebral Disc (IVD) height is not changed at 12 months after intradiscal injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs)
2025-01-29 10-39-27A reduction in posterior Intervertebral Disc (IVD) bulge size by >= 25% correlates with better NPS scores compared with <25% at 6 months post-injection of an average of 23 million Hypoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into the Nucleus Pulposus and Annulus Fibrosus of L4-L5 or L5-S1
2025-01-29 10-20-4434% of people between 20-39 have an asymptomatic degenerated Intervertebral Disc (IVD) of the Lumbar Spine
2025-01-29 10-27-2285% of patients have a decrease in posterior Intervertebral Disc (IVD) bulge size 6 months on average post-injection of an average of 23 million Hypoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into the Nucleus Pulposus and Annulus Fibrosus of L4-L5 or L5-S1
2025-01-29 10-17-2956% of people between 20-39 have an asymptomatic bulging Intervertebral Disc (IVD) of the Lumbar Spine
2025-01-29 10-19-3021% of people between 20-39 have an asymptomatic herniated Intervertebral Disc (IVD) in the Lumbar Spine
Quick Notes1
2025-01-28 19-04-29Forskolin inhibits the progression of Intervertebral Disc (IVD) degeneration
Assumptions6
2025-01-29 09-37-15The results for lutzClinicalOutcomesFollowing2022 can be extrapolated to all Intervertebral Disc (IVD) issues
2025-01-28 21-25-18The methods used to assess Intervertebral Disc (IVD) hydration in orozcoIntervertebralDiscRepair2011 are valid
2025-01-28 21-20-02The effect of Urolithin A on Intervertebral Disc (IVD) degeneration in response to IVD puncture is the same for rats of all ages
2025-01-28 21-03-50Intervertebral Disc (IVD) degeneration progresses similarly between rats and humans
2025-01-28 21-02-30Intervertebral Disc (IVD) degeneration progresses similarly amongst rats of all ages in response to a puncture model
2025-01-28 20-53-52An Intervertebral Disc (IVD) puncture is an appropriate model for assessing IVD degeneration in rats