IGF1

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Insights29
2025-01-30 14-40-02The reduction in circulating IGF1 availability during fasting is responsible for the fasting-induced symmetric Self-Renewal of mouse Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) after 72-hour Prolonged Fasting
2025-01-30 14-14-19Serum IGF1 levels are reduced by ~45% in mice during a 4-day Fasting-Mimicking Diet (FMD)
2025-01-30 14-07-34Refeeding with ~0.4 g/kg protein after 5-day Prolonged Fasting allows serum IGF1 levels to continue decreasing when refeeding with 552-799 kcal/day (10.8 kcal/kg) but not 1797-2579 kcal/day (35.1 kcal/kg)
2025-01-30 14-05-11Serum IGF1 levels are reduced to ~200 ng/mL in mice during a 4-day Fasting-Mimicking Diet (FMD)
2025-01-30 12-28-26Plasma levels of IGF1 are reduced by 70% in mice after 72-hour Prolonged Fasting compared with non-fasting mice
2025-01-29 11-25-02Prolonged Fasting for 9 days after 3 days of Calorie Restriction reduces serum IGF1 by at least 71%
2025-01-30 12-05-44Injecting IGF1 into fasting mice prevented an increase in the ratio of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) to total bone marrow cells at 72 hours of Prolonged Fasting compared with 72-hour-fasted mice that were not injected with IGF1 while fasting
2025-01-30 11-55-39Injecting IGF1 into fasting mice prevented an increase in the number of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) at 72 hours of Prolonged Fasting compared with 72-hour-fasted mice that were not injected with IGF1 while fasting
2025-01-29 11-26-23Prolonged Fasting for 9 days reduces circulating IGF1 by 71%
2025-01-29 11-24-22Prolonged Fasting for 72 hours reduces circulating IGF1 levels by 70-75% in mice
2025-01-29 11-23-24Prolonged Fasting for 7 days reduces circulating IGF1 by 62%
2025-01-29 11-06-02Prolonged Fasting for 3 days reduces circulating IGF1 levels by 41-54%
2025-01-29 11-05-25Prolonged Fasting for 7 days after 3 days of Calorie Restriction reduces serum IGF1 by at least 62%
2025-01-29 11-04-37Prolonged Fasting for 5 days reduces serum IGF1 by 64%
2025-01-29 11-04-24Prolonged Fasting for 5 days reduces circulating IGF1 levels by 53-64%
2025-01-29 11-03-54Prolonged Fasting for 5 days after 3 days of Calorie Restriction reduces serum IGF1 by at least 53%
2025-01-29 11-02-49Prolonged Fasting for 4 days reduces serum IGF1 levels by 59%
2025-01-29 11-02-36Prolonged Fasting for 4 days reduces circulating IGF1 levels by 59%
2025-01-29 11-01-45Prolonged Fasting for 3 days reduces serum IGF1 by 54%
2025-01-29 11-01-02Prolonged Fasting for 3 days reduces serum IGF1 by 42%
2025-01-29 11-00-47Prolonged Fasting for 3 days after 3 days of Calorie Restriction reduces serum IGF1 by at least 41%
2025-01-29 10-57-40Prolonged Fasting for 10 days after 3 days of Calorie Restriction reduces serum IGF1 by at least 75%
2025-01-29 10-52-38Prolonged Fasting for 10 days reduces circulating IGF1 by 75%
2025-01-29 10-47-07Circulating IGF1 is reduced by ~75% at the end of 72-hour Prolonged Fasting compared with non-fasting mice
2025-01-29 10-35-559 days of water-only Prolonged Fasting in humans is equivalent to a 3-day water-only fast in mice in terms of its effects on IGF1 availability
2025-01-29 10-31-114 days of Buchinger Fasting (max 250 kcal per day) reduces plasma IGF1 by ~51%
2025-01-29 10-27-593 days of water-only Prolonged Fasting is at least equivalent to a 4-day mouse Fasting-Mimicking Diet (FMD) in terms of its effects on IGF1 availability
2025-01-29 10-17-2648 hours of Prolonged Fasting reduces serum IGF1 by ~66% in 6-month-old mice
2025-01-29 10-17-2248 hours of Prolonged Fasting does not reduce serum IGF1 in 24-month-old mice
Quick Notes6
2025-01-27 16-23-55Complete Protein Restriction reduces plasma IGF1 levels by 50% in mice
2025-01-27 16-20-59Restricting just one of the Essential Amino Acids (EAAs) (Leucine, Lysine, Methionine, or Threonine) reduces plasma IGF1 levels by 34% in mice
2025-01-27 15-26-04Serum IGF1 is reduced by 37% at the end of a 96-hour fast during Prolonged Fasting in nonobese people
2025-01-27 15-25-06Serum IGF1 is reduced by 16% at the end of a 48-hour fast during Prolonged Fasting in nonobese people
2025-01-27 15-22-17People with Type 2 Diabetes do not experience the same changes in IGF1 during Prolonged Fasting as non-diabetics
2025-01-27 15-21-24Obese people do not experience the same changes in IGF1 during Prolonged Fasting as nonobese people
Assumptions4
2025-01-28 21-32-52The reduction in IGF1 availability during a fast is responsible for the effects of Prolonged Fasting and Refeeding on Senescent Cells
2025-01-28 21-13-21The control values for serum IGF1 in clemmonsReductionPlasmaImmunoreactive1981 were measured at the 3rd day of Calorie Restriction immediately before the Prolonged Fasting period started
2025-01-28 21-12-39The Calorie Restriction before Prolonged Fasting in clemmonsReductionPlasmaImmunoreactive1981 did not affect the changes in serum IGF1 levels seen during the fast
2025-01-28 20-48-16% changes in circulating IGF1 levels act as an adequate proxy for assessing changes in IGF1 availability