Fasting-Mimicking Diet (FMD)

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2025-01-30 15-39-20p16 expression is reduced in Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) in the bone marrow of 22-month-old mice at 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 15-38-45p16 expression is not reduced in Short-Term Hematopoietic Stem Cells (ST-HSCs) or Multipotent Progenitors (MPPs) in the bone marrow of 22-month-old mice at 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 15-37-51Whole-body expression of p16 is reduced in 11-month-old mice at the end of a second consecutive monthly Fasting-Mimicking Diet (FMD) cycle
2025-01-30 15-07-48 (WIP)Undergoing a Fasting-Mimicking Diet (FMD) cycle causes an increase in total Bone Marrow Mesenchymal Stem Cells (BMMSCs) in mouse bone marrow
2025-01-30 15-06-49Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the ratio of lin-Sca1+CD45- Bone Marrow Mesenchymal Stem Cells (BMMSCs) to total bone marrow cells at 7 days after Refeeding in 20.5-month-old mice compared to age-matched controls
2025-01-30 15-06-32Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the ratio of BrdU+ lin-Sca1+CD45- cells to total bone marrow cells at 7 days after Refeeding following BrdU treatment in 20.5-month-old mice compared to age-matched controls
2025-01-30 15-05-43Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of proliferating lin-Sca1+CD45- Bone Marrow Mesenchymal Stem Cells (BMMSCs) in mouse bone marrow at 7 days after Refeeding in 20.5-month-old mice compared to age-matched controls
2025-01-30 15-04-37Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of proliferating lin-Sca1+CD45- bone marrow cells at 7 days after Refeeding in 20.5-month-old mice compared to age-matched controls
2025-01-30 15-04-10Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of proliferating Bone Marrow Mesenchymal Stem Cells (BMMSCs) in mouse bone marrow at 7 days after Refeeding
2025-01-30 15-01-49Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of proliferating Bone Marrow Mesenchymal Stem Cells (BMMSCs) in mouse bone marrow at 7 days after Refeeding in 20.5-month-old mice compared to age-matched controls
2025-01-30 15-00-30Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of BrdU+ lin-Sca1+CD45- BM cells at 7 days after Refeeding following BrdU treatment in 20.5-month-old mice compared to age-matched controls
2025-01-30 14-58-12Two consecutive monthly Fasting-Mimicking Diet (FMD) cycles can reduce the number of Senescent Cells throughout the body
2025-01-30 14-57-31There are fewer Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) Senescent Cells in the bone marrow of mice 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 14-53-57The serum IGF1-IGFBP1 Ratio is reduced by ~94% in mice during a 4-day Fasting-Mimicking Diet (FMD)
2025-01-30 14-26-56The % of cas3+p16+ Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) increases from ~1% to ~3% in the bone marrow of 22-month-old mice at 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 14-25-13The % of cas3+p16+ Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) in 22-month-old mice is not affected by a Fasting-Mimicking Diet (FMD) cycle
2025-01-30 14-24-58The % of cas3+ Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) increases from ~1% to ~3% in the bone marrow of 22-month-old mice at 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 14-23-59The % of cas3+ Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) in 22-month-old mice is not affected by a Fasting-Mimicking Diet (FMD) cycle
2025-01-30 14-15-44Serum IGFBP1 levels are increased by ~800% in mice during a 4-day Fasting-Mimicking Diet (FMD)
2025-01-30 14-14-19Serum IGF1 levels are reduced by ~45% in mice during a 4-day Fasting-Mimicking Diet (FMD)
2025-01-30 14-05-50Refeeding causes Apoptosis in Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) Senescent Cells following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 14-05-11Serum IGF1 levels are reduced to ~200 ng/mL in mice during a 4-day Fasting-Mimicking Diet (FMD)
2025-01-30 13-54-39Refeeding after a Fasting-Mimicking Diet (FMD) causes Senescent Cells of various types throughout the body to die off
2025-01-30 13-53-46Refeeding after an Fasting-Mimicking Diet (FMD) cycle causes a reduction in Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) Senescent Cells specifically due to Apoptosis
2025-01-29 10-27-593 days of water-only Prolonged Fasting is at least equivalent to a 4-day mouse Fasting-Mimicking Diet (FMD) in terms of its effects on IGF1 availability
2025-01-29 10-24-28A 4-day Fasting-Mimicking Diet (FMD) does not negatively effect the Lean Mass of mice when undergoing FMD cycles twice per month
2025-01-29 10-19-5628-month old mice who have been doing 4-day Fasting-Mimicking Diet (FMD) cycles twice per month for 12 months have the same amount of Lean Mass between FMD cycles as their non-fasted counterparts
Assumptions13
2025-01-28 20-51-20A Fasting-Mimicking Diet (FMD) cycle had the same general effect on BrdU incorporation into Bone Marrow Mesenchymal Stem Cells (BMMSCs) regardless of FMD cycle number in the brandhorstPeriodicDietThat2015 study
2025-01-29 09-35-00The results for cas3+p16+ cells in figure 1D of the longoUtilizationFastingMimickingDiet2023 patent would be the same during a Fasting-Mimicking Diet (FMD) cycle as they are shown at the end of an FMD cycle
2025-01-29 09-36-02The results for lean mass in 28-month-old mice in the brandhorstPeriodicDietThat2015 - Figure 1I would hold true for mice after any number of Fasting-Mimicking Diet (FMD) cycles
2025-01-29 09-35-27The results for cas3+p16+ cells in figure 1D of the longoUtilizationFastingMimickingDiet2023 patent would be the same regardless of the number of consecutive Fasting-Mimicking Diet (FMD) cycles performed
2025-01-29 09-34-34The results for cas3+ cells in figure 1C of the longoUtilizationFastingMimickingDiet2023 patent would be the same regardless of the number of consecutive Fasting-Mimicking Diet (FMD) cycles performed
2025-01-29 09-33-55The results for cas3+ cells in figure 1C of the longoUtilizationFastingMimickingDiet2023 patent would be the same during a Fasting-Mimicking Diet (FMD) cycle as they are shown at the end of an FMD cycle
2025-01-28 21-28-50The number of p16- Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) did not increase in 22-month-old mice at 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles in longoUtilizationFastingMimickingDiet2023 - Figure 1D
2025-01-28 21-26-33The mouse Fasting-Mimicking Diet (FMD) used in longoUtilizationFastingMimickingDiet2023 was the same as the mouse FMD used in brandhorstPeriodicDietThat2015
2025-01-28 21-24-08The monthly Fasting-Mimicking Diet (FMD) was administered consecutively to mice in the longoUtilizationFastingMimickingDiet2023 patent
2025-01-28 21-19-18The effect of Fasting-Mimicking Diet (FMD) cycles on Senescent Cells does not depend on age
2025-01-28 20-52-50A Fasting-Mimicking Diet (FMD) cycle would have had the same general effect on BrdU incorporation into Bone Marrow Mesenchymal Stem Cells (BMMSCs) regardless of mouse age in the brandhorstPeriodicDietThat2015 study
2025-01-28 20-50-38A Fasting-Mimicking Diet (FMD) cycle had the same general effect on increasing total Bone Marrow Mesenchymal Stem Cells (BMMSCs) number regardless of FMD cycle number in the brandhorstPeriodicDietThat2015 study
2025-01-28 20-48-01A Fasting-Mimicking Diet (FMD) cycle would have had the same general effect on increasing total Bone Marrow Mesenchymal Stem Cells (BMMSCs) number regardless of mouse age in the brandhorstPeriodicDietThat2015 study