2025-01-31 14-23-42
Content
- A Ketogenic Diet can worsen the progression of Knee Osteoarthritis in mice who maintain Beta-Hydroxybutyrate (BHB) levels ~ 1.28 mM compared to control rats with BHB levels ~0.87 mM when ketogenic-diet-fed mice lose weight post-injury and control mice do not. This is potentially due to ketogenic-diet-induced changes in the Gut Microbiome. Ketogenic diet protein composition 22.4% of calories and control diet protein composition 24% of calories.
References
| Original Sources1 | Citations |
|---|---|
| dysonKetogenicDietAssociatedWorsening2025 | Dyson, Gabby, Montana Barrett, Leoni Schlupp, Emmaline Prinz, Nicholas Hannebut, Aleksander Szymczak, Cindy Miranda Brawner, and Matlock A. Jeffries. “Ketogenic Diet-Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice.” ACR Open Rheumatology 7, no. 1 (January 2025): e11794. https://doi.org/10.1002/acr2.11794. |