2025-01-30 15-34-35

Content

Urolithin A slows the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A

Insights5
2025-01-30 15-37-02	Urolithin A slows the reduction in Intervertebral Disc (IVD) histological score at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-32-27	Urolithin A slows the progression in Intervertebral Disc (IVD) Pfirrmann Grade at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-17-08	Urolithin A increases the Intervertebral Disc (IVD) disc height index at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-15-20	Urolithin A increases the Intervertebral Disc (IVD) Collagen Type II fluorescence at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-14-32	Urolithin A increases the Intervertebral Disc (IVD) Aggrecan fluorescence at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A

Original Sources1	Citations
shiUrolithinAlleviatesOxidative2021	Shi, Peng-Zhi, Jun-Wu Wang, Ping-Chuan Wang, Bo Han, Xu-Hua Lu, Yong-Xin Ren, Xin-Min Feng, Xiao-Fei Cheng, and Liang Zhang. “Urolithin a Alleviates Oxidative Stress-Induced Senescence in Nucleus Pulposus-Derived Mesenchymal Stem Cells through SIRT1/PGC-1α Pathway.” World Journal of Stem Cells 13, no. 12 (December 26, 2021): 1928–46. https://doi.org/10.4252/wjsc.v13.i12.1928.