2025-01-30 15-33-56

Content

Urolithin A slows the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 12 weeks of age compared to rats not fed urolithin A

Insights3
2025-01-30 15-35-56	Urolithin A slows the progressive loss of Intervertebral Disc (IVD) height at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 12 weeks of age compared to rats not fed Urolithin A
2025-01-30 15-34-20	Urolithin A slows the progression of Pfirrmann Grade at a dose of 25 mg/kg/day when taken for 4 weeks after an Intervertebral Disc (IVD) puncture at 12 weeks of age compared to rats not fed urolithin A
2025-01-30 15-31-32	Urolithin A slows the increase in histologic score at a dose of 25 mg/kg/day when taken for 4 weeks after an Intervertebral Disc (IVD) puncture at 12 weeks of age compared to rats not fed urolithin A

Original Sources1	Citations
liuUrolithinInhibitsCatabolic2018	Liu, Huiyong, Honglei Kang, Chao Song, Zuowei Lei, Li Li, Jianfeng Guo, Yong Xu, Hanfeng Guan, Zhong Fang, and Feng Li. “Urolithin A Inhibits the Catabolic Effect of TNFα on Nucleus Pulposus Cell and Alleviates Intervertebral Disc Degeneration in Vivo.” Frontiers in Pharmacology 9 (2018): 1043. https://doi.org/10.3389/fphar.2018.01043.