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Content
- Urolithin A reduces the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 8 weeks of age compared to rats not fed urolithin A
References
| Insights3 | |
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| 2025-01-30 15-28-05 | Urolithin A reduces the number of TUNEL-positive cells in the Nucleus Pulposus at a dose of 25 mg/kg/day when taken for 4 weeks after an Intervertebral Disc (IVD) puncture at 8 weeks of age compared to rats not fed urolithin A |
| 2025-01-30 15-25-18 | Urolithin A reduces the Intervertebral Disc (IVD) histological score at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 8 weeks of age compared to rats not fed urolithin A |
| 2025-01-30 15-24-17 | Urolithin A reduces the Intervertebral Disc (IVD) Pfirrmann Grade at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 8 weeks of age compared to rats not fed urolithin A |
| Original Sources1 | Citations |
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| linUrolithinAinducedMitophagy2020 | Lin, Jialiang, Jinru Zhuge, Xuanqi Zheng, Yuhao Wu, Zengjie Zhang, Tianzhen Xu, Zaher Meftah, et al. “Urolithin A-Induced Mitophagy Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the AMPK Signaling Pathway.” Free Radical Biology & Medicine 150 (April 2020): 109–19. https://doi.org/10.1016/j.freeradbiomed.2020.02.024. |