2025-01-30 15-23-29

Content

Urolithin A reduces markers of the progression of knee Osteoarthritis at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age

Insights3
2025-01-30 15-30-53	Urolithin A reduces the serum levels of Matrix Metalloproteinase-3 (MMP3) in mice at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-26-59	Urolithin A reduces the knee OARSI score of mice at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-18-26	Urolithin A increases the cell number in non-calcified knee Cartilage of mice at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age

Original Sources1	Citations
damicoUrolithinImprovesMitochondrial2022	D’Amico, Davide, Merissa Olmer, Andréane M. Fouassier, Pamela Valdés, Pénélope A. Andreux, Chris Rinsch, and Martin Lotz. “Urolithin A Improves Mitochondrial Health, Reduces Cartilage Degeneration, and Alleviates Pain in Osteoarthritis.” Aging Cell 21, no. 8 (August 2022): e13662. https://doi.org/10.1111/acel.13662.