2025-01-30 15-05-43

Content

Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of proliferating lin-Sca1+CD45- Bone Marrow Mesenchymal Stem Cells (BMMSCs) in mouse bone marrow at 7 days after Refeeding in 20.5-month-old mice compared to age-matched controls

References

Assumptions1
2025-01-28 21-23-03	The lin-Sca1+CD45- cells analyzed in brandhorstPeriodicDietThat2015 - Figure 2T were all Bone Marrow Mesenchymal Stem Cells (BMMSCs)

Insights1
2025-01-30 15-04-37	Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of proliferating lin-Sca1+CD45- bone marrow cells at 7 days after Refeeding in 20.5-month-old mice compared to age-matched controls

Original Sources1	Citations
brandhorstPeriodicDietThat2015	Brandhorst, S., Choi, I.Y., Wei, M., Cheng, C.W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L.P., Park, R., Vinciguerra, M., Di Biase, S., Mirzaei, H., Mirisola, M.G., Childress, P., Ji, L., Groshen, S., Penna, F., Odetti, P., Perin, L., Conti, P.S., Ikeno, Y., Kennedy, B.K., Cohen, P., Morgan, T.E., Dorff, T.B., Longo, V.D., 2015. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab 22, 86–99. https://doi.org/10.1016/j.cmet.2015.05.012

Original Sources1

Citations

brandhorstPeriodicDietThat2015

Brandhorst, S., Choi, I.Y., Wei, M., Cheng, C.W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L.P., Park, R., Vinciguerra, M., Di Biase, S., Mirzaei, H., Mirisola, M.G., Childress, P., Ji, L., Groshen, S., Penna, F., Odetti, P., Perin, L., Conti, P.S., Ikeno, Y., Kennedy, B.K., Cohen, P., Morgan, T.E., Dorff, T.B., Longo, V.D., 2015. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab 22, 86–99. https://doi.org/10.1016/j.cmet.2015.05.012