2025-01-30 14-40-02
Content
- The reduction in circulating IGF1 availability during fasting is responsible for the fasting-induced symmetric Self-Renewal of mouse Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) after 72-hour Prolonged Fasting
References
| Assumptions1 | |
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| 2025-01-28 20-48-16 | % changes in circulating IGF1 levels act as an adequate proxy for assessing changes in IGF1 availability |
| Insights3 | |
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| 2025-01-30 11-55-39 | Injecting IGF1 into fasting mice prevented an increase in the number of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) at 72 hours of Prolonged Fasting compared with 72-hour-fasted mice that were not injected with IGF1 while fasting |
| 2025-01-29 11-24-44 | Prolonged Fasting for 72 hours induces symmetric Self-Renewal of mouse Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) |
| 2025-01-29 11-24-22 | Prolonged Fasting for 72 hours reduces circulating IGF1 levels by 70-75% in mice |
| Original Sources2 | Citations |
|---|---|
| chengProlongedFastingReduces2014 | Cheng, C.-W., Adams, G.B., Perin, L., Wei, M., Zhou, X., Lam, B.S., Da Sacco, S., Mirisola, M., Quinn, D.I., Dorff, T.B., Kopchick, J.J., Longo, V.D., 2014. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell 14, 810–823. https://doi.org/10.1016/j.stem.2014.04.014 |
| leeReducedLevelsIGFI2010 | Lee, C., Safdie, F.M., Raffaghello, L., Wei, M., Madia, F., Parrella, E., Hwang, D., Cohen, P., Bianchi, G., Longo, V.D., 2010. Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index. Cancer Research 70, 1564–1572. https://doi.org/10.1158/0008-5472.CAN-09-3228 |