2025-01-30 13-56-42
Content
- Reducing expression of th Protein Kinase A Catalytic Subunit (PKACα) in mouse bone marrow causes proliferation of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs)
References
| Insights2 | |
|---|---|
| 2025-01-29 10-57-27 | Ex vivo treatment of cells from mouse bone marrow with siRNA targeting the Protein Kinase A (PKA) catalytic subunit (Protein Kinase A Catalytic Subunit (PKACα)) increases the ratio of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) to total cells compared with untreated cells |
| 2025-01-29 10-53-18 | Ex-vivo treatment of cells from mouse bone marrow with siRNA targeting the Protein Kinase A (PKA) catalytic subunit (Protein Kinase A Catalytic Subunit (PKACα)) does not affect the total number of cells compared to untreated cells |
| Original Sources1 | Citations |
|---|---|
| chengProlongedFastingReduces2014 | Cheng, C.-W., Adams, G.B., Perin, L., Wei, M., Zhou, X., Lam, B.S., Da Sacco, S., Mirisola, M., Quinn, D.I., Dorff, T.B., Kopchick, J.J., Longo, V.D., 2014. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell 14, 810–823. https://doi.org/10.1016/j.stem.2014.04.014 |