2025-01-29 11-24-22

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2025-01-30 12-28-26Plasma levels of IGF1 are reduced by 70% in mice after 72-hour Prolonged Fasting compared with non-fasting mice
2025-01-29 10-47-07Circulating IGF1 is reduced by ~75% at the end of 72-hour Prolonged Fasting compared with non-fasting mice
Original Sources2Citations
chengProlongedFastingReduces2014Cheng, C.-W., Adams, G.B., Perin, L., Wei, M., Zhou, X., Lam, B.S., Da Sacco, S., Mirisola, M., Quinn, D.I., Dorff, T.B., Kopchick, J.J., Longo, V.D., 2014. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell 14, 810–823. https://doi.org/10.1016/j.stem.2014.04.014
leeReducedLevelsIGFI2010Lee, C., Safdie, F.M., Raffaghello, L., Wei, M., Madia, F., Parrella, E., Hwang, D., Cohen, P., Bianchi, G., Longo, V.D., 2010. Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index. Cancer Research 70, 1564–1572. https://doi.org/10.1158/0008-5472.CAN-09-3228