2025-01-29 10-43-15
Content
- A Urolithin A dose of 250 mg/kg/day is likely better than a dose of 50 mg/kg/day at reducing the pain from knee Osteoarthritis in mice when taken for 8 weeks after the induction of experimental arthritis at 4 months of age
References
| Assumptions1 | |
|---|---|
| 2025-01-28 20-49-14 | A Von Frey test is an appropriate test for assessing pain for knee Osteoarthritis in mice |
| Insights2 | |
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| 2025-01-30 15-21-19 | Urolithin A may reduce the pain response to a 4g Von Frey filament at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 4 weeks after the induction of experimental Osteoarthritis at 4 months of age |
| 2025-01-30 15-20-59 | Urolithin A may reduce the pain from knee Osteoarthritis in mice at a dose of either 250 mg/kg/day or 50 mg/kg/day when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age |
| Original Sources1 | Citations |
|---|---|
| damicoUrolithinImprovesMitochondrial2022 | D’Amico, Davide, Merissa Olmer, Andréane M. Fouassier, Pamela Valdés, Pénélope A. Andreux, Chris Rinsch, and Martin Lotz. “Urolithin A Improves Mitochondrial Health, Reduces Cartilage Degeneration, and Alleviates Pain in Osteoarthritis.” Aging Cell 21, no. 8 (August 2022): e13662. https://doi.org/10.1111/acel.13662. |