2025-01-29 10-39-27

Content

A reduction in posterior Intervertebral Disc (IVD) bulge size by >= 25% correlates with better NPS scores compared with <25% at 6 months post-injection of an average of 23 million Hypoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into the Nucleus Pulposus and Annulus Fibrosus of L4-L5 or L5-S1

References

Source Content4
centenoTreatmentLumbarDegenerative2017 - Results (posterior IVD dimension)
centenoTreatmentLumbarDegenerative2017 - Results (Demographics)
centenoTreatmentLumbarDegenerative2017 - Methods (isolation and expansion of MSCs)
centenoTreatmentLumbarDegenerative2017 - Methods (IVD injection protocol)

Original Sources1	Citations
centenoTreatmentLumbarDegenerative2017	Centeno, Christopher, Jason Markle, Ehren Dodson, Ian Stemper, Christopher J. Williams, Matthew Hyzy, Thomas Ichim, and Michael Freeman. “Treatment of Lumbar Degenerative Disc Disease-Associated Radicular Pain with Culture-Expanded Autologous Mesenchymal Stem Cells: A Pilot Study on Safety and Efficacy.” Journal of Translational Medicine 15, no. 1 (September 22, 2017): 197. https://doi.org/10.1186/s12967-017-1300-y.

Original Sources1

Citations

centenoTreatmentLumbarDegenerative2017

Centeno, Christopher, Jason Markle, Ehren Dodson, Ian Stemper, Christopher J. Williams, Matthew Hyzy, Thomas Ichim, and Michael Freeman. “Treatment of Lumbar Degenerative Disc Disease-Associated Radicular Pain with Culture-Expanded Autologous Mesenchymal Stem Cells: A Pilot Study on Safety and Efficacy.” Journal of Translational Medicine 15, no. 1 (September 22, 2017): 197. https://doi.org/10.1186/s12967-017-1300-y.