2025-01-29 10-27-59

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References

Assumptions1
2025-01-28 20-48-16% changes in circulating IGF1 levels act as an adequate proxy for assessing changes in IGF1 availability
Insights2
2025-01-30 14-14-19Serum IGF1 levels are reduced by ~45% in mice during a 4-day Fasting-Mimicking Diet (FMD)
2025-01-29 11-06-02Prolonged Fasting for 3 days reduces circulating IGF1 levels by 41-54%
Original Sources4Citations
clemmonsReductionPlasmaImmunoreactive1981CLEMMONS, D.R., KLIBANSKI, A., UNDERWOOD, L.E., McARTHUR, J.W., RIDGWAY, E.C., BEITINS, I.Z., VAN WYK, J.J., 1981. Reduction of Plasma Immunoreactive Somatomedin C during Fasting in Humans*. The Journal of Clinical Endocrinology & Metabolism 53, 1247–1250. https://doi.org/10.1210/jcem-53-6-1247
merimeeInsulinlikeGrowthFactors1982Merimee, T.J., Zapf, J., Froesch, E.R., 1982. Insulin-like growth factors in the fed and fasted states. J Clin Endocrinol Metab 55, 999–1002. https://doi.org/10.1210/jcem-55-5-999
isleyDietaryComponentsThat1983Isley, W.L., Underwood, L.E., Clemmons, D.R., 1983. Dietary components that regulate serum somatomedin-C concentrations in humans. J Clin Invest 71, 175–182. https://doi.org/10.1172/JCI110757
brandhorstPeriodicDietThat2015Brandhorst, S., Choi, I.Y., Wei, M., Cheng, C.W., Sedrakyan, S., Navarrete, G., Dubeau, L., Yap, L.P., Park, R., Vinciguerra, M., Di Biase, S., Mirzaei, H., Mirisola, M.G., Childress, P., Ji, L., Groshen, S., Penna, F., Odetti, P., Perin, L., Conti, P.S., Ikeno, Y., Kennedy, B.K., Cohen, P., Morgan, T.E., Dorff, T.B., Longo, V.D., 2015. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab 22, 86–99. https://doi.org/10.1016/j.cmet.2015.05.012