2025-01-20 20-19-43

Content

Muscle Stem Cells (MuSCs, Satellite Stem Cells) have reduced content of Mitochondria (number and/or size) in mice at the end of 7 days of 3x/day intraperitoneal 200 mg/kg Beta-Hydroxybutyrate (BHB) + 200 mg/kg Acetoacetate (AcAc) injections compared to control mice as assessed by MitoTracker and MitoSox

References

Assumptions1
2025-01-20 20-25-36	The difference between groups in benjaminFastingInducesHighly2022 - Figure 2F is statistically significant

Source Content8
benjaminFastingInducesHighly2022 - Materials and methods (histology and immunochemistry)
benjaminFastingInducesHighly2022 - Materials and methods (drug treatments)
benjaminFastingInducesHighly2022 - Materials and methods (dietary intervention)
benjaminFastingInducesHighly2022 - Materials and methods (animals)
benjaminFastingInducesHighly2022 - Materials and methods (MuSC isolation)
benjaminFastingInducesHighly2022 - Materials and methods (MuSC flow cytometry analysis)
benjaminFastingInducesHighly2022 - Figure 2F
benjaminFastingInducesHighly2022 - Figure 2E

Original Sources1	Citations
benjaminFastingInducesHighly2022	Benjamin, D.I., Both, P., Benjamin, J.S., Nutter, C.W., Tan, J.H., Kang, J., Machado, L.A., Klein, J.D.D., Morree, A. de, Kim, S., Liu, L., Dulay, H., Feraboli, L., Louie, S.M., Nomura, D.K., Rando, T.A., 2022. Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling. Cell Metabolism 34, 902-918.e6. https://doi.org/10.1016/j.cmet.2022.04.012