2025-01-20 20-12-30

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2025-01-29 11-46-14Muscle Stem Cells (MuSCs, Satellite Stem Cells) are reduced in size by ~10% in mice by the end of 1 week of 3x/day intraperitoneal 200 mg/kg racemic Racemic Beta-Hydroxybutyrate (DL-BHB) and 200 mg/kg Acetoacetate (AcAc) injections compared to control mice
2025-01-20 20-41-50Fewer Muscle Stem Cells (MuSCs, Satellite Stem Cells) from mice treated with intraperitoneal injections of 200 mg/kg/day Beta-Hydroxybutyrate (BHB) + 200 mg/kg/day Acetoacetate (AcAc) are in S Phase compared to control mice as assessed by Edu incorporation
2025-01-20 20-37-16Fewer Muscle Stem Cells (MuSCs, Satellite Stem Cells) enter S Phase when cultured ex vivo when the stem cells are isolated from mice treated with 3x/day intraperitoneal injections of 200 mg/kg Beta-Hydroxybutyrate (BHB) + 200 mg/kg Acetoacetate (AcAc) compared to control mice as assessed by EdU incorporation
2025-01-20 20-32-54Muscle Stem Cells (MuSCs, Satellite Stem Cells) exhibit reduced basal oxygen consumption at the end of 7 days of 3x/day intraperitoneal 200 mg/kg Beta-Hydroxybutyrate (BHB) + 200 mg/kg Acetoacetate (AcAc) injections in mice compared with control mice
2025-01-20 20-19-43Muscle Stem Cells (MuSCs, Satellite Stem Cells) have reduced content of Mitochondria (number and/or size) in mice at the end of 7 days of 3x/day intraperitoneal 200 mg/kg Beta-Hydroxybutyrate (BHB) + 200 mg/kg Acetoacetate (AcAc) injections compared to control mice as assessed by MitoTracker and MitoSox
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benjaminFastingInducesHighly2022Benjamin, D.I., Both, P., Benjamin, J.S., Nutter, C.W., Tan, J.H., Kang, J., Machado, L.A., Klein, J.D.D., Morree, A. de, Kim, S., Liu, L., Dulay, H., Feraboli, L., Louie, S.M., Nomura, D.K., Rando, T.A., 2022. Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling. Cell Metabolism 34, 902-918.e6. https://doi.org/10.1016/j.cmet.2022.04.012