2025-01-20 18-28-57

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2025-01-29 11-46-14Muscle Stem Cells (MuSCs, Satellite Stem Cells) are reduced in size by ~10% in mice by the end of 1 week of 3x/day intraperitoneal 200 mg/kg racemic Racemic Beta-Hydroxybutyrate (DL-BHB) and 200 mg/kg Acetoacetate (AcAc) injections compared to control mice
2025-01-20 19-12-04Muscle Stem Cells (MuSCs, Satellite Stem Cells) have reduced RNA content in mice at the end of 2.5-day Prolonged Fasting compared to non-fasted mice as assessed by Pyronin Y
2025-01-20 19-29-10Fewer Muscle Stem Cells (MuSCs, Satellite Stem Cells) from mice undergoing 2.5-day Prolonged Fasting are in S Phase at 72 hours after muscle injury compared to non-fasted mice as assessed by EdU incorporation
2025-01-20 19-21-47Fewer Muscle Stem Cells (MuSCs, Satellite Stem Cells) enter S Phase when cultured ex vivo when the stem cells are isolated from mice after 2.5-day Prolonged Fasting mice compared to non-fasted mice as assessed by EdU incorporation
2025-01-20 19-17-51Muscle Stem Cells (MuSCs, Satellite Stem Cells) exhibit reduced basal oxygen consumption at the end of 2.5-day Prolonged Fasting in mice compared with non-fasted mice
2025-01-20 18-42-42Muscle Stem Cells (MuSCs, Satellite Stem Cells) have ~40% reduced content of Mitochondria (number and/or size) in mice at the end of 2.5-day Prolonged Fasting compared to non-fasted mice as assessed by MitoTracker
Original Sources1Citations
benjaminFastingInducesHighly2022Benjamin, D.I., Both, P., Benjamin, J.S., Nutter, C.W., Tan, J.H., Kang, J., Machado, L.A., Klein, J.D.D., Morree, A. de, Kim, S., Liu, L., Dulay, H., Feraboli, L., Louie, S.M., Nomura, D.K., Rando, T.A., 2022. Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling. Cell Metabolism 34, 902-918.e6. https://doi.org/10.1016/j.cmet.2022.04.012