2025-01-20 16-01-27
Content
- The capability of mouse muscle for Regeneration may be reduced when blood Beta-Hydroxybutyrate (BHB) levels are ~1.9-2.25 mM at the time of injury compared to ~0.4 mM
References
| Assumptions1 | |
|---|---|
| 2025-01-29 09-39-30 | The results shown in benjaminFastingInducesHighly2022 - Figure 1C are due specifically to blood Beta-Hydroxybutyrate (BHB) levels and not to other physiological changes that occur during fasting |
| Insights4 | |
|---|---|
| 2025-01-30 12-22-21 | Mice have a blood Beta-Hydroxybutyrate (BHB) level of ~2.25 mM after 48 hours of Prolonged Fasting |
| 2025-01-20 15-29-22 | Fasting mice for 1 or 2 days prior to muscle injury results in the same muscle Regeneration following 7 days of Refeeding |
| 2025-01-20 15-42-14 | Mice fasting for 24 hours have a blood Beta-Hydroxybutyrate (BHB) level of ~1.9 mM |
| 2025-01-20 15-39-52 | Non-fasting mice can have a resting blood Beta-Hydroxybutyrate (BHB) level of ~0.4 mM |
| Original Sources1 | Citations |
|---|---|
| benjaminFastingInducesHighly2022 | Benjamin, D.I., Both, P., Benjamin, J.S., Nutter, C.W., Tan, J.H., Kang, J., Machado, L.A., Klein, J.D.D., Morree, A. de, Kim, S., Liu, L., Dulay, H., Feraboli, L., Louie, S.M., Nomura, D.K., Rando, T.A., 2022. Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling. Cell Metabolism 34, 902-918.e6. https://doi.org/10.1016/j.cmet.2022.04.012 |