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2025-01-20 15-07-10	Fasting mice for 1-2.5 days prior to muscle injury reduces muscle Regeneration following 7 days of Refeeding compared to no fasting prior to injury
2025-01-20 15-10-32	Fasting mice for as little as 1 day prior to muscle injury reduces muscle Regeneration following 7 days of Refeeding
2025-01-20 15-18-43	Fasting mice for 2.5 days prior to muscle injury reduces muscle Regeneration following 7 days of Refeeding compared to fasting for 1 day prior to injury
2025-01-20 15-24-25	Fasting mice for 2.5 days prior to muscle injury reduces muscle Regeneration following 7 days of Refeeding compared to fasting for 2 days prior to injury
2025-01-20 15-29-22	Fasting mice for 1 or 2 days prior to muscle injury results in the same muscle Regeneration following 7 days of Refeeding
2025-01-20 15-39-52	Non-fasting mice can have a resting blood Beta-Hydroxybutyrate (BHB) level of ~0.4 mM
2025-01-20 15-42-14	Mice fasting for 24 hours have a blood Beta-Hydroxybutyrate (BHB) level of ~1.9 mM
2025-01-20 15-44-11	Mice have a blood Beta-Hydroxybutyrate (BHB) level of ~2.75 mM after 60 hours of Prolonged Fasting
2025-01-20 16-01-27	The capability of mouse muscle for Regeneration may be reduced when blood Beta-Hydroxybutyrate (BHB) levels are ~1.9-2.25 mM at the time of injury compared to ~0.4 mM
2025-01-20 16-08-05	The capacity of mouse muscle for Regeneration may be reduced when blood Beta-Hydroxybutyrate (BHB) levels are ~2.25 mM at the time of injury compared to ~1.9-2.25 mM
2025-01-20 16-46-34	Mice following a Ketogenic Diet for 20 days have a blood Beta-Hydroxybutyrate (BHB) level of ~2.1 mM
2025-01-20 16-54-40	Following a Ketogenic Diet for 3 weeks prior to and after muscle injury reduces muscle Regeneration at 7 days post-injury compared to following a standard diet prior to and following injury
2025-01-20 18-28-57	Muscle Stem Cells (MuSCs, Satellite Stem Cells) enter a state of Deep Quiescence at the end of 2.5-day Prolonged Fasting in mice
2025-01-20 18-42-42	Muscle Stem Cells (MuSCs, Satellite Stem Cells) have ~40% reduced content of Mitochondria (number and/or size) in mice at the end of 2.5-day Prolonged Fasting compared to non-fasted mice as assessed by MitoTracker
2025-01-20 19-12-04	Muscle Stem Cells (MuSCs, Satellite Stem Cells) have reduced RNA content in mice at the end of 2.5-day Prolonged Fasting compared to non-fasted mice as assessed by Pyronin Y
2025-01-20 19-17-51	Muscle Stem Cells (MuSCs, Satellite Stem Cells) exhibit reduced basal oxygen consumption at the end of 2.5-day Prolonged Fasting in mice compared with non-fasted mice
2025-01-20 19-21-47	Fewer Muscle Stem Cells (MuSCs, Satellite Stem Cells) enter S Phase when cultured ex vivo when the stem cells are isolated from mice after 2.5-day Prolonged Fasting mice compared to non-fasted mice as assessed by EdU incorporation
2025-01-20 19-29-10	Fewer Muscle Stem Cells (MuSCs, Satellite Stem Cells) from mice undergoing 2.5-day Prolonged Fasting are in S Phase at 72 hours after muscle injury compared to non-fasted mice as assessed by EdU incorporation
2025-01-20 19-40-29	Muscle Stem Cells (MuSCs, Satellite Stem Cells) are reduced in size by ~10% in mice who followed a Ketogenic Diet for 3 weeks compared with mice on a control diet
2025-01-20 19-43-12	Muscle Stem Cells (MuSCs, Satellite Stem Cells) enter a state of Deep Quiescence at the end of 3 weeks on a Ketogenic Diet in mice
2025-01-20 19-47-43	Muscle Stem Cells (MuSCs, Satellite Stem Cells) have ~40% reduced content of Mitochondria (number and/or size) in mice after following a Ketogenic Diet for 3 weeks compared to mice on a control diet as assessed by MitoTracker
2025-01-20 19-52-51	Fewer Muscle Stem Cells (MuSCs, Satellite Stem Cells) enter S Phase when cultured ex vivo when the stem cells are isolated from mice following a Ketogenic Diet for 3 weeks compared to mice on a standard diet as assessed by EdU incorporation
2025-01-20 20-12-30	Muscle Stem Cells (MuSCs, Satellite Stem Cells) enter a state of Deep Quiescence at the end of 1 week of 3x/day intraperitoneal injections of 200 mg/kg Beta-Hydroxybutyrate (BHB) + 200 mg/kg Acetoacetate (AcAc) in mice
2025-01-20 20-19-43	Muscle Stem Cells (MuSCs, Satellite Stem Cells) have reduced content of Mitochondria (number and/or size) in mice at the end of 7 days of 3x/day intraperitoneal 200 mg/kg Beta-Hydroxybutyrate (BHB) + 200 mg/kg Acetoacetate (AcAc) injections compared to control mice as assessed by MitoTracker and MitoSox
2025-01-20 20-32-54	Muscle Stem Cells (MuSCs, Satellite Stem Cells) exhibit reduced basal oxygen consumption at the end of 7 days of 3x/day intraperitoneal 200 mg/kg Beta-Hydroxybutyrate (BHB) + 200 mg/kg Acetoacetate (AcAc) injections in mice compared with control mice
2025-01-20 20-37-16	Fewer Muscle Stem Cells (MuSCs, Satellite Stem Cells) enter S Phase when cultured ex vivo when the stem cells are isolated from mice treated with 3x/day intraperitoneal injections of 200 mg/kg Beta-Hydroxybutyrate (BHB) + 200 mg/kg Acetoacetate (AcAc) compared to control mice as assessed by EdU incorporation
2025-01-20 20-41-50	Fewer Muscle Stem Cells (MuSCs, Satellite Stem Cells) from mice treated with intraperitoneal injections of 200 mg/kg/day Beta-Hydroxybutyrate (BHB) + 200 mg/kg/day Acetoacetate (AcAc) are in S Phase compared to control mice as assessed by Edu incorporation
2025-01-29 10-17-06	20.5-month-old mice have a lower ratio of lin-Sca1+CD45- cells to total bone marrow cells compared to 8-10-month-old mice
2025-01-29 10-17-22	48 hours of Prolonged Fasting does not reduce serum IGF1 in 24-month-old mice
2025-01-29 10-17-26	48 hours of Prolonged Fasting reduces serum IGF1 by ~66% in 6-month-old mice
2025-01-29 10-17-29	56% of people between 20-39 have an asymptomatic bulging Intervertebral Disc (IVD) of the Lumbar Spine
2025-01-29 10-19-30	21% of people between 20-39 have an asymptomatic herniated Intervertebral Disc (IVD) in the Lumbar Spine
2025-01-29 10-19-56	28-month old mice who have been doing 4-day Fasting-Mimicking Diet (FMD) cycles twice per month for 12 months have the same amount of Lean Mass between FMD cycles as their non-fasted counterparts
2025-01-29 10-20-44	34% of people between 20-39 have an asymptomatic degenerated Intervertebral Disc (IVD) of the Lumbar Spine
2025-01-29 10-22-31	70% of patients who undergo intradiscal leukocyte-rich >10X Platelet-Rich Plasma (PRP) notice improvement within the first 12 weeks
2025-01-29 10-23-03	72 hours of Prolonged Fasting around Chemotherapy is better at keeping blood Lymphocyte counts from reducing than fasting for 24 hours around chemotherapy for platinum-based doublet chemotherapy
2025-01-29 10-24-05	81% of people who have intradiscal leukocyte-rich >10X Platelet-Rich Plasma (PRP) are satisfied with their injection
2025-01-29 10-24-28	A 4-day Fasting-Mimicking Diet (FMD) does not negatively effect the Lean Mass of mice when undergoing FMD cycles twice per month
2025-01-29 10-24-39	A person weighing 70 kg needs as much as 13 g Glycine per day from their diet
2025-01-29 10-27-22	85% of patients have a decrease in posterior Intervertebral Disc (IVD) bulge size 6 months on average post-injection of an average of 23 million Hypoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into the Nucleus Pulposus and Annulus Fibrosus of L4-L5 or L5-S1
2025-01-29 10-27-59	3 days of water-only Prolonged Fasting is at least equivalent to a 4-day mouse Fasting-Mimicking Diet (FMD) in terms of its effects on IGF1 availability
2025-01-29 10-29-47	4 days of Buchinger Fasting (max 250 kcal per day) increases plasma IGFBP1 by ~159%
2025-01-29 10-31-11	4 days of Buchinger Fasting (max 250 kcal per day) reduces plasma IGF1 by ~51%
2025-01-29 10-31-43	4 days of Buchinger Fasting (max 250 kcal per day) reduces the plasma IGF1-IGFBP1 Ratio by ~81%
2025-01-29 10-35-05	A mouse dose in mg/kg can be divided by 12.3 to approximate an equivalent human dose in mg/kg
2025-01-29 10-35-55	9 days of water-only Prolonged Fasting in humans is equivalent to a 3-day water-only fast in mice in terms of its effects on IGF1 availability
2025-01-29 10-38-49	A rat dose in mg/kg can be divided by 6.2 to approximate an equivalent human dose in mg/kg
2025-01-29 10-39-17	A Urolithin A dose of 2.5 mg/kg/day in a mouse is equivalent to 0.2 mg/kg/day in a human
2025-01-29 10-39-27	A reduction in posterior Intervertebral Disc (IVD) bulge size by >= 25% correlates with better NPS scores compared with <25% at 6 months post-injection of an average of 23 million Hypoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into the Nucleus Pulposus and Annulus Fibrosus of L4-L5 or L5-S1
2025-01-29 10-40-59	A Urolithin A dose greater than 0.2 mg/kg may relieve pain from constriction of the Sciatic Nerve
2025-01-29 10-41-13	A Urolithin A dose of 25 mg/kg/day in a rat equates to 4 mg/kg/day in a human
2025-01-29 10-42-32	A Urolithin A dose of 250 mg/kg/day in a mouse equates to 20.3 mg/kg/day in a human
2025-01-29 10-43-15	A Urolithin A dose of 250 mg/kg/day is likely better than a dose of 50 mg/kg/day at reducing the pain from knee Osteoarthritis in mice when taken for 8 weeks after the induction of experimental arthritis at 4 months of age
2025-01-29 10-43-59	Alternate-Day Fasting (ADF) for 9 months increases the number of Lin-Sca1+CD45- Very Small Embryonic-Like Stem Cells (VSELs) compared to no fasting in the bone marrow of 10-month-old mice
2025-01-29 10-44-28	Alternate-Day Fasting (ADF) for 9 months increases the ratio of Lin-Sca1+CD45- Very Small Embryonic-Like Stem Cells (VSELs) to total Bone Marrow Mononuclear Cells (BMMNCs) compared to no fasting in the bone marrow of 10-month-old mice
2025-01-29 10-45-52	Chemical Radiculitis can be resolved with intradiscal 10X Platelet-Rich Plasma (PRP) within two weeks
2025-01-29 10-45-55	Chemical Radiculitis can be resolved with an epidural
2025-01-29 10-45-58	Chemical Radiculitis can be present with negative Straight-Leg Raise Test
2025-01-29 10-46-01	Chemical Radiculitis can be worse while standing
2025-01-29 10-46-05	Chemical Radiculitis can affect both legs when a tear is on one side of the Annulus Fibrosus
2025-01-29 10-46-08	Chemical Radiculitis can affect both legs when a tear is in the middle of the Annulus Fibrosus
2025-01-29 10-46-32	Daily intraperitoneal injections of 2.5 mg/kg Urolithin A in mice reduce pain from chronic Sciatic Nerve constriction compared to mice not administered urolithin A
2025-01-29 10-47-07	Circulating IGF1 is reduced by ~75% at the end of 72-hour Prolonged Fasting compared with non-fasting mice
2025-01-29 10-47-58	Chemical Radiculitis can be worse when sitting
2025-01-29 10-51-11	A tear in the Annulus Fibrosus may require Contrast-enhanced Magnetic Resonance Imaging (MRI) in order to be seen
2025-01-29 10-52-06	Daily intraperitoneal injections of 2.5 mg/kg Urolithin A in mice reduce the pain-related behavioral deficits from chronic Sciatic Nerve constriction compared to mice not administered urolithin A when injections begin immediately after constriction surgery
2025-01-29 10-52-14	Intervertebral Disc (IVD) height is not changed at 12 months after intradiscal injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs)
2025-01-29 10-52-31	Excluding input from dietary proteins, there is a net balance of -11.5 grams of Glycine per day for a person weighing 70 kg
2025-01-29 10-52-38	Prolonged Fasting for 10 days reduces circulating IGF1 by 75%
2025-01-29 10-53-18	Ex-vivo treatment of cells from mouse bone marrow with siRNA targeting the Protein Kinase A (PKA) catalytic subunit (Protein Kinase A Catalytic Subunit (PKACα)) does not affect the total number of cells compared to untreated cells
2025-01-29 10-53-58	Intervertebral Disc (IVD) bulges, disc protrusions, and discs with normal contours but abnormal heights and-or T2 signal intensities on Magnetic Resonance Imaging (MRI) are highly likely to indicate the presence of a tear in the inner Annulus Fibrosus
2025-01-29 10-54-58	Intervertebral Disc (IVD) hydration is increased by an average of 16% at 12 months after intradiscal injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs)
2025-01-29 10-55-56	Discopathy should be the term used to collectively refer to Intervertebral Disc (IVD) bulges and disc protrusions and discs with normal contours but abnormal heights and-or T2 signal intensities on Magnetic Resonance Imaging (MRI)
2025-01-29 10-57-27	Ex vivo treatment of cells from mouse bone marrow with siRNA targeting the Protein Kinase A (PKA) catalytic subunit (Protein Kinase A Catalytic Subunit (PKACα)) increases the ratio of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) to total cells compared with untreated cells
2025-01-29 10-57-40	Prolonged Fasting for 10 days after 3 days of Calorie Restriction reduces serum IGF1 by at least 75%
2025-01-29 11-00-47	Prolonged Fasting for 3 days after 3 days of Calorie Restriction reduces serum IGF1 by at least 41%
2025-01-29 11-01-02	Prolonged Fasting for 3 days reduces serum IGF1 by 42%
2025-01-29 11-01-45	Prolonged Fasting for 3 days reduces serum IGF1 by 54%
2025-01-29 11-02-36	Prolonged Fasting for 4 days reduces circulating IGF1 levels by 59%
2025-01-29 11-02-49	Prolonged Fasting for 4 days reduces serum IGF1 levels by 59%
2025-01-29 11-03-54	Prolonged Fasting for 5 days after 3 days of Calorie Restriction reduces serum IGF1 by at least 53%
2025-01-29 11-04-24	Prolonged Fasting for 5 days reduces circulating IGF1 levels by 53-64%
2025-01-29 11-04-37	Prolonged Fasting for 5 days reduces serum IGF1 by 64%
2025-01-29 11-05-25	Prolonged Fasting for 7 days after 3 days of Calorie Restriction reduces serum IGF1 by at least 62%
2025-01-29 11-06-02	Prolonged Fasting for 3 days reduces circulating IGF1 levels by 41-54%
2025-01-29 11-23-24	Prolonged Fasting for 7 days reduces circulating IGF1 by 62%
2025-01-29 11-24-22	Prolonged Fasting for 72 hours reduces circulating IGF1 levels by 70-75% in mice
2025-01-29 11-24-44	Prolonged Fasting for 72 hours induces symmetric Self-Renewal of mouse Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs)
2025-01-29 11-25-02	Prolonged Fasting for 9 days after 3 days of Calorie Restriction reduces serum IGF1 by at least 71%
2025-01-29 11-26-23	Prolonged Fasting for 9 days reduces circulating IGF1 by 71%
2025-01-29 11-46-14	Muscle Stem Cells (MuSCs, Satellite Stem Cells) are reduced in size by ~10% in mice by the end of 1 week of 3x/day intraperitoneal 200 mg/kg racemic Racemic Beta-Hydroxybutyrate (DL-BHB) and 200 mg/kg Acetoacetate (AcAc) injections compared to control mice
2025-01-30 11-55-39	Injecting IGF1 into fasting mice prevented an increase in the number of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) at 72 hours of Prolonged Fasting compared with 72-hour-fasted mice that were not injected with IGF1 while fasting
2025-01-30 12-05-44	Injecting IGF1 into fasting mice prevented an increase in the ratio of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) to total bone marrow cells at 72 hours of Prolonged Fasting compared with 72-hour-fasted mice that were not injected with IGF1 while fasting
2025-01-30 12-06-46	Injecting leukocyte-rich >10X Platelet-Rich Plasma (PRP) into a pain-generating Intervertebral Disc (IVD) is successful in 70% of patients as assessed by NRS pain score, FRI, and patient satisfaction
2025-01-30 12-10-44	It takes 48-72 hours of Prolonged Fasting for Protein Kinase A (PKA) activity to decrease in the bone marrow cells of mice
2025-01-30 12-11-56	Back Pain in the Lumbar Spine is reduced by an average of 62% at 3 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into a non-torn Intervertebral Disc (IVD) at L5-S1, L4-L5, or both levels
2025-01-30 12-13-47	Back Pain in the Lumbar Spine is reduced by an average of 69% at 6 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into a non-torn Intervertebral Disc (IVD) at L5-S1, L4-L5, or both levels
2025-01-30 12-15-27	Back Pain in the Lumbar Spine is reduced by an average of 71% at 12 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into a non-torn Intervertebral Disc (IVD) at L5-S1, L4-L5, or both levels
2025-01-30 12-18-13	Mice eat ~4g food per day when they are 4 months old
2025-01-30 12-22-21	Mice have a blood Beta-Hydroxybutyrate (BHB) level of ~2.25 mM after 48 hours of Prolonged Fasting
2025-01-30 12-28-26	Plasma levels of IGF1 are reduced by 70% in mice after 72-hour Prolonged Fasting compared with non-fasting mice
2025-01-30 12-47-40	Mice weigh ~30g at 4 months of age
2025-01-30 13-50-44	Rats weigh up to ~255g when they are 8 weeks old
2025-01-30 13-51-06	Plasma levels of IGFBP3 are decreased by 42% in mice after 72-hour Prolonged Fasting compared with non-fasting mice
2025-01-30 13-51-11	Plasma levels of IGFBP1 are increased by 11.4-fold after 72-hour Prolonged Fasting compared with non-fasted mice
2025-01-30 13-53-46	Refeeding after an Fasting-Mimicking Diet (FMD) cycle causes a reduction in Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) Senescent Cells specifically due to Apoptosis
2025-01-30 13-54-39	Refeeding after a Fasting-Mimicking Diet (FMD) causes Senescent Cells of various types throughout the body to die off
2025-01-30 13-56-42	Reducing expression of th Protein Kinase A Catalytic Subunit (PKACα) in mouse bone marrow causes proliferation of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs)
2025-01-30 13-58-04	Rats eat up to ~23 grams of food per day at 6-7 weeks of age
2025-01-30 13-58-41	Rats eat up to ~23 grams of food per day at 6-12 weeks of age
2025-01-30 13-59-03	Rats eat up to ~22 grams of food per day at 11-12 weeks of age
2025-01-30 14-02-08	Neuropathy and/or Chemical Radiculitis can be resolved within 12 weeks of injecting 10X Platelet-Rich Plasma (PRP) into the Intervertebral Disc (IVD)
2025-01-30 14-05-11	Serum IGF1 levels are reduced to ~200 ng/mL in mice during a 4-day Fasting-Mimicking Diet (FMD)
2025-01-30 14-05-50	Refeeding causes Apoptosis in Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) Senescent Cells following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 14-07-34	Refeeding with ~0.4 g/kg protein after 5-day Prolonged Fasting allows serum IGF1 levels to continue decreasing when refeeding with 552-799 kcal/day (10.8 kcal/kg) but not 1797-2579 kcal/day (35.1 kcal/kg)
2025-01-30 14-08-07	Sciatica is not significantly reduced at 3 months after after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into a non-torn Intervertebral Disc (IVD) at L5-S1, L4-L5, or both levels
2025-01-30 14-12-07	Sciatica is reduced by an average of 79% at 6 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into the Intervertebral Disc (IVD)
2025-01-30 14-13-16	Sciatica is reduced by an average of 86% at 12 months after injection of 10±5 million Normoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into the Intervertebral Disc (IVD)
2025-01-30 14-13-57	Senescent Cells accumulate throughout the body with Aging
2025-01-30 14-14-19	Serum IGF1 levels are reduced by ~45% in mice during a 4-day Fasting-Mimicking Diet (FMD)
2025-01-30 14-15-44	Serum IGFBP1 levels are increased by ~800% in mice during a 4-day Fasting-Mimicking Diet (FMD)
2025-01-30 14-16-21	Taking Urolithin A with high-protein yogurt (17 grams) in the morning while fasting does not impact the bioavailability of urolithin A at doses of 500 mg or 1000 mg
2025-01-30 14-20-22	The % of mouse Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) in G0 Phase is reduced at the end of 72-hour Prolonged Fasting compared with non-fasting mice
2025-01-30 14-21-44	The % of mouse Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) in G1 Phase is increased at the end of 72-hour Prolonged Fasting compared with non-fasting mice
2025-01-30 14-22-58	The % of mouse Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) in S-G2-M is increased at the end of 72-hour Prolonged Fasting compared with non-fasting mice
2025-01-30 14-23-59	The % of cas3+ Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) in 22-month-old mice is not affected by a Fasting-Mimicking Diet (FMD) cycle
2025-01-30 14-24-58	The % of cas3+ Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) increases from ~1% to ~3% in the bone marrow of 22-month-old mice at 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 14-25-13	The % of cas3+p16+ Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) in 22-month-old mice is not affected by a Fasting-Mimicking Diet (FMD) cycle
2025-01-30 14-26-56	The % of cas3+p16+ Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) increases from ~1% to ~3% in the bone marrow of 22-month-old mice at 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 14-28-44	The enhanced Self-Renewal program of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) from mice after 72-hour Prolonged Fasting is inherent to the LT-HSC cells and not related to the BM stromal niche cells
2025-01-30 14-29-17	The ideal single dose for injecting Hypoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) into the Annulus Fibrosus of a torn L5-S1 Intervertebral Disc (IVD) to improve overall quality of life after 4+ years may be 35.9 million cells
2025-01-30 14-30-40	The number of Bone Marrow Mesenchymal Stem Cells (BMMSCs) in mouse bone marrow decreases with age
2025-01-30 14-33-50	The number of Bone Marrow Mesenchymal Stem Cells (BMMSCs) in the bone marrow decreases with age
2025-01-30 14-40-02	The reduction in circulating IGF1 availability during fasting is responsible for the fasting-induced symmetric Self-Renewal of mouse Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) after 72-hour Prolonged Fasting
2025-01-30 14-41-07	The ratio of total Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) to total bone marrow cells in mouse bone marrow is increased in mice after 72-hour Prolonged Fasting compared to non-fasting mice
2025-01-30 14-43-30	The ratio of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) to total CD45+ cells increases for LT-HSCs isolated from the bone marrow of mice after 72-hour Prolonged Fasting mice compared to those of non-fasted mice upon 3-day co-culture with Lin-CD45- stromal cells from the bone marrow of non-fasted mice
2025-01-30 14-44-30	The ratio of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) to total CD45+ cells increases for LT-HSCs isolated from the BM of mice after 72-hour Prolonged Fasting compared to those of non-fasted mice upon 3-day co-culture with Lin-CD45- stromal cells from the bone marrow of 72-hour-fasted mice
2025-01-30 14-45-54	The ratio of BrdU+ Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) to total bone marrow cells in mouse bone marrow is increased in mice after 72-hour Prolonged Fasting compared to non-fasting mice
2025-01-30 14-46-24	The number of lin-Sca1+CD45- cells in mouse bone marrow decreases with age
2025-01-30 14-47-02	The number of lin-Sca1+CD45- Bone Marrow Mesenchymal Stem Cells (BMMSCs) in mouse bone marrow decreases with age
2025-01-30 14-48-20	The number of Hypoxic-Cultured Autologous Mesenchymal Stem Cells (MSCs) injected into the Annulus Fibrosus of a torn L5-S1 Intervertebral Disc (IVD) may positively correlate with overall improvement in quality of life after 4+ years
2025-01-30 14-53-57	The serum IGF1-IGFBP1 Ratio is reduced by ~94% in mice during a 4-day Fasting-Mimicking Diet (FMD)
2025-01-30 14-54-39	The total number of Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) in mouse bone marrow increases by the end of 72-hour Prolonged Fasting
2025-01-30 14-55-51	The total number of cells in the bone marrow of mice is no different between mice at the end of 72-hour Prolonged Fasting vs. non-fasting mice.
2025-01-30 14-56-06	The total number of cycling Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) in mouse bone marrow increases by the end of 72-hour Prolonged Fasting
2025-01-30 14-57-31	There are fewer Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) Senescent Cells in the bone marrow of mice 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 14-58-12	Two consecutive monthly Fasting-Mimicking Diet (FMD) cycles can reduce the number of Senescent Cells throughout the body
2025-01-30 15 28 41	Urolithin A reduces the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 8 weeks of age compared to rats not fed urolithin A
2025-01-30 15-00-30	Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of BrdU+ lin-Sca1+CD45- BM cells at 7 days after Refeeding following BrdU treatment in 20.5-month-old mice compared to age-matched controls
2025-01-30 15-01-49	Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of proliferating Bone Marrow Mesenchymal Stem Cells (BMMSCs) in mouse bone marrow at 7 days after Refeeding in 20.5-month-old mice compared to age-matched controls
2025-01-30 15-04-10	Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of proliferating Bone Marrow Mesenchymal Stem Cells (BMMSCs) in mouse bone marrow at 7 days after Refeeding
2025-01-30 15-04-37	Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of proliferating lin-Sca1+CD45- bone marrow cells at 7 days after Refeeding in 20.5-month-old mice compared to age-matched controls
2025-01-30 15-05-43	Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the number of proliferating lin-Sca1+CD45- Bone Marrow Mesenchymal Stem Cells (BMMSCs) in mouse bone marrow at 7 days after Refeeding in 20.5-month-old mice compared to age-matched controls
2025-01-30 15-06-32	Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the ratio of BrdU+ lin-Sca1+CD45- cells to total bone marrow cells at 7 days after Refeeding following BrdU treatment in 20.5-month-old mice compared to age-matched controls
2025-01-30 15-06-49	Undergoing a 4-day Fasting-Mimicking Diet (FMD) once every two weeks starting at 16 months of age increases the ratio of lin-Sca1+CD45- Bone Marrow Mesenchymal Stem Cells (BMMSCs) to total bone marrow cells at 7 days after Refeeding in 20.5-month-old mice compared to age-matched controls
2025-01-30 15-07-48 (WIP)	Undergoing a Fasting-Mimicking Diet (FMD) cycle causes an increase in total Bone Marrow Mesenchymal Stem Cells (BMMSCs) in mouse bone marrow
2025-01-30 15-11-44	Urolithin A can reduce the pain response to a 1g Von Frey filament at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-14-32	Urolithin A increases the Intervertebral Disc (IVD) Aggrecan fluorescence at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-15-20	Urolithin A increases the Intervertebral Disc (IVD) Collagen Type II fluorescence at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-17-08	Urolithin A increases the Intervertebral Disc (IVD) disc height index at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-18-26	Urolithin A increases the cell number in non-calcified knee Cartilage of mice at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-18-57	Urolithin A may reduce knee Sinovitis at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-20-59	Urolithin A may reduce the pain from knee Osteoarthritis in mice at a dose of either 250 mg/kg/day or 50 mg/kg/day when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-21-19	Urolithin A may reduce the pain response to a 4g Von Frey filament at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 4 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-23-01	Urolithin A may reduce the pain response to a 4g Von Frey filament at a dose of either 250 mg/kg/day or 50 mg/kg/day compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-23-29	Urolithin A reduces markers of the progression of knee Osteoarthritis at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-24-17	Urolithin A reduces the Intervertebral Disc (IVD) Pfirrmann Grade at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 8 weeks of age compared to rats not fed urolithin A
2025-01-30 15-25-18	Urolithin A reduces the Intervertebral Disc (IVD) histological score at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 8 weeks of age compared to rats not fed urolithin A
2025-01-30 15-26-59	Urolithin A reduces the knee OARSI score of mice at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-28-05	Urolithin A reduces the number of TUNEL-positive cells in the Nucleus Pulposus at a dose of 25 mg/kg/day when taken for 4 weeks after an Intervertebral Disc (IVD) puncture at 8 weeks of age compared to rats not fed urolithin A
2025-01-30 15-30-53	Urolithin A reduces the serum levels of Matrix Metalloproteinase-3 (MMP3) in mice at a dose of 250 mg/kg/day, but not 50 mg/kg/day, compared to control when taken for 8 weeks after the induction of experimental Osteoarthritis at 4 months of age
2025-01-30 15-31-32	Urolithin A slows the increase in histologic score at a dose of 25 mg/kg/day when taken for 4 weeks after an Intervertebral Disc (IVD) puncture at 12 weeks of age compared to rats not fed urolithin A
2025-01-30 15-32-27	Urolithin A slows the progression in Intervertebral Disc (IVD) Pfirrmann Grade at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-33-56	Urolithin A slows the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 12 weeks of age compared to rats not fed urolithin A
2025-01-30 15-34-20	Urolithin A slows the progression of Pfirrmann Grade at a dose of 25 mg/kg/day when taken for 4 weeks after an Intervertebral Disc (IVD) puncture at 12 weeks of age compared to rats not fed urolithin A
2025-01-30 15-34-35	Urolithin A slows the progression of Intervertebral Disc (IVD) degeneration at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-35-56	Urolithin A slows the progressive loss of Intervertebral Disc (IVD) height at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 12 weeks of age compared to rats not fed Urolithin A
2025-01-30 15-36-46	Whole-body expression of p16 increases in mice as they age
2025-01-30 15-37-02	Urolithin A slows the reduction in Intervertebral Disc (IVD) histological score at a dose of 25 mg/kg/day when taken for 4 weeks after an IVD puncture at 4-6 months of age compared to rats not fed urolithin A
2025-01-30 15-37-51	Whole-body expression of p16 is reduced in 11-month-old mice at the end of a second consecutive monthly Fasting-Mimicking Diet (FMD) cycle
2025-01-30 15-38-45	p16 expression is not reduced in Short-Term Hematopoietic Stem Cells (ST-HSCs) or Multipotent Progenitors (MPPs) in the bone marrow of 22-month-old mice at 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles
2025-01-30 15-39-20	p16 expression is reduced in Bone Marrow Long-Term Hematopoietic Stem Cells (BM LT-HSCs) in the bone marrow of 22-month-old mice at 24 hours after Refeeding following two consecutive Fasting-Mimicking Diet (FMD) cycles